After eating a cursed pizza, Shaggy starts to grow into a Godzilla-like monster whenever he goes to sleep, and he starts eating everything in sight. Now the gang are running around Tokyo trying to get away from the police who want to capture Shaggy.
While in Egypt on an archeological dig with Melbourne O'Reilly, the gang encounters Pharaoh Scamses XV - a mummy who has a knack of turning tourists into zombie minions. Even worse for the gang is the fact that they are in danger of being turned into zombies themselves.
The gang travels to an old Transylvanian castle on a rainy night to watch the shoot of the Hex Girls' new music video Wanna Wed, But I Fled. But when they get there, they find out that the band is breaking up, since there's a vampire on the loose. Fred decides to go straight to trapping the vampire. They do so, only to discover there's another vampire lurking around. It's up to Scooby and the gang to solve the mystery and prevent the Hex Girls from breaking up.
After the gang votes on their destination they end up at the annual dog show courtesy of Scooby. There Shaggy runs into an old acquaintance Meadow and her dog, M'Lady Moonbeam. However, the gang then has an unpleasant run-in with a cat creature who seems bent on ruining the dog-show and stealing the puppies of former winner dog, Crissie.
On route to a rock festival, the gang runs into Simple Plan. As both their vans are wrecked they have to spend the night at a nearby ghost town. And worse yet it soon becomes obvious that something invisible is out to get Simple Plan.
After Shaggy wins a trip to the Scooby Snacks Factory The gang prepares for a well deserved holiday. Unfortunately there is very high security in the factory due to spies and worst of all the ghost of a former employee who died in the Scooby Snacks paste vat is lurking in the shadows.
An ancient bird kidnaps locals from a Native American reservation in New Mexico, where Shaggy, Scooby, and the gang visits Shaggy's old friend, Jimmy Proudwolf and his dog, Shooby. Shaggy is about to enter a contest with a sculpture he made of Scooby's head, but the bird steals it, right before kidnapping Daphne.