The Space Ghost team (Space Ghost, Jan, Jace, and Blip) was attacked by Moltar and Zorak, and forced to crash land on Earth. Moltar and Zorak sent a message to the Department of Astrophysical Research claiming that an Extraterrestrial Phantom was going to attack, and they asked Mystery Inc. for help. Just then, the Space Ghost team appeared, causing panic throughout the facility. Shaggy was captured by Blip, but was set free on the behest of Daphne. Space Ghost came to ask for help to fix his ship and find his villains. The facility tracked the signal of the warning to the moon, and gave Space Ghost the supplies to fix his ship and alter the Mystery Machine for space flight.
They landed on the moon, by Trannquility Base, and discover a modern cable leading away from the base. Unknowing to Space Ghost, Jan and Jace were kidnapped just before entering the base. After entering the base, they are encountered by Moltar and Zorak and their goons. They protected themselves from the goons, but Zorak tried to blackmail Space Ghost by threatening the lives of those he kidnapped. However, it was not Jan and Jace who were kidnapped, but Daphne and Fred in their uniforms. They freed themselves, and distracted the villains long enough for Blip to pull a lever releasing lava across the base. They all escaped, and Space Ghost knocked out the villains. They traveled back to Earth, and re-modified the Mystery Machine back to normal.
- Space Ghost (first full appearance)(final appearance)
- Jace (only appearance)
- Jan (only appearance)
- Blip (first full appearance)(only comic appearance)
- Zorak (first full appearance)(only comic appearance)(final appearance)
- Moltar (first full appearance)(only comic appearance)(final appearance)
- Molten Men (only appearance)(no lines)
- Miscellaneous Zorathians (only appearance)(no lines)
- Miscellaneous scientists (only appearance)(miscellaneous speaking)
- Beach ball
- Molten magma cannon (destroyed)
The following credits try to match how they are displayed in the comic as much as possible:
- Writer: Sholly Fisch
- Artist: Dario Brizuela
- Colorist: Franco Riesco
- Letterer: Saida Temofonte
- Cover artist: Brizuela with Riesco
- Editor: Brittany Holzherr
- Special thanks to: Kristy Quinn
- The issue is dedicated to C. Martin Croker and Don Messick, respectively. Messick was the voice of Blip and Zorak in the original Space Ghost cartoon (not to mention the original Scooby-Doo), while Croker was the voice of Zorak and Moltar in the parody spin-off, Space Ghost Coast to Coast.
- Fred alludes to the fact that the Scooby-Doo, Where Are You? and Team-Up comics are being released in the same month.
- Shaggy calls Jace and Jan, "space kidettes," which was the name of a Hanna-Barbera cartoon about a group of child astronauts.
- Space Ghost Coast to Coast is retconned as being the result of Space Ghost being hypnotized by Zorak into believing it was real. Incidentally, DC Comics happened to do several issues of Cartoon Network Presents based on Space Ghost Coast to Coast.
- None known.
Inconsistencies/continuity errors and/or goofs/oddities
- An actress played Jan in DC Comics' Scooby-Doo story Sound Stage Spook.
- The world of Space Ghost was also fictionalized in the direct-to-video film Scooby-Doo! Mask of the Blue Falcon.
- The gang act like they've never been on the moon, despite the fact they went there in the direct-to-video film Scooby-Doo! Moon Monster Madness.
- The comic says Space Ghost was a talk-show host for eight seasons, when it actually ran for ten. The first eight were ran across Cartoon Network and Adult Swim, while the last two were aired on the pay service site GameTap.