Shaggy Rogers and Daphne Blake may refer to the following:
- Shaggy Rogers and Daphne Blake: An article detailing the relationship of the original incarnations of Shaggy Rogers and Daphne Blake.
- Shaggy Rogers and Daphne Blake: The relationship of the incarnations in Scooby-Doo! Mystery Incorporated.
- Shaggy Rogers and Daphne Blake: The relationship of the incarnations in Be Cool, Scooby-Doo!
- Shaggy Rogers and Daphne Blake: Their relationship in Scooby-Doo! Curse of the Lake Monster.