- This article is about Scooby and Daphne in standard continuity. For Scooby and Daphne in other continuities, see Scooby-Doo and Daphne Blake (disambiguation).
Scooby-Doo and Daphne Blake are best friends in Mystery Inc.
Having known each other from childhood, Daphne and Scooby have a very special bond. Daphne loves Scooby as if he was her dog. She loves him how he is, a large and lovable Great Dane. Scooby barely licks Daphne as a sign of affection, but he also loves her and shares that sweet bond that Daphne has for him. Daphne can get really scared or worried about him if he is gone or going to do something dangerous. She would then would scream Scooby's name in horror by saying, "Scooby Doo where are you!?" or tell him to be careful.
A Pup Named Scooby-Doo
When they were going inside Scooby's dog house (which turns out to be a mansion inside) to look for clues, Daphne was impressed with Scooby's dog house. 
When Shaggy Rogers and Scooby had a falling out, the others hoped that they would make up. In the end, Daphne had Shaggy thank Scooby for saving him, having enough of them arguing, which he accepted.
When Velma Dinkley got suspended, the gang went back to school to clear her name. When the Dinkley 2000 captured Daphne, Freddie Jones and Shaggy, Scooby and Velma worked together to overload the robot, saving the others.
The Scooby-Doo Show
Scooby-Doo and the Cyber Chase
When the gang were first informed about the Phantom Virus, Scooby-Doo reacted by hiding behind a desk, which Daphne responded to by kneeling down and petting Scooby to comfort him. On the moon level of Cyber Space, she cheered for him and told him to be careful while he was going to get the Scooby Snax. In the third level of the game she told him to be careful when he climbing up the volcano to rescue the baby pterodactyl.
Scooby-Doo! in Where's My Mummy?
When Daphne was afraid that Velma got turned into stone, she was so worried about Scooby. Saying the quote, "Scooby Doo, where are you!?". Scooby was upset that Velma was turned to "stone", so Daphne went to comfort him by giving him a hug and returning his collar back to him.
Scooby-Doo! and the Goblin King
When Scooby splashed water on Daphne and Velma, both girls scolded him.
She was worried about him and Shaggy, after they had disappeared.
When the gang was cornered by Krudsky, she screamed "Scooby Doo where are you!?"
After Daphne, Fred, and Velma got their memories erased by the Goblin King, Scooby and Shaggy arrived with the Mystery Machine, with Daphne being relieved that Scooby and Shaggy were okay and saying Scooby's name in relief.
Chill Out Scooby Doo!
When Scooby and Shaggy were stuck in the Himalayas, Daphne and the rest of the gang left Paris to find them. When Daphne was worried about Scooby after the gang found Pemba on the mountain, she looked worried and held her hands together when saying, "Scooby Doo, where are you?". It resulted in a loud echo.
Scooby-Doo! and the Samurai Sword
Daphne said Scooby is such a ham when Scooby was posing cutely and took pictures of Scooby while he stood next to the statue of Hachikō.
- The Sludge Monster from the Earth's Core (episode)
- APNSD: Night of the Living Burger, season 2, episode 5.
- APNSD: The Computer Walks Among Us, season 2, episode 6.
- Scooby-Doo and the Cyber Chase, direct-to-video film 4.
- Scooby-Doo! in Where's My Mummy?, direct-to-video film 9.
- Scooby-Doo! and the Goblin King, direct-to-video film 12.
- Scooby-Doo! and the Samurai Sword, direct-to-video film 13.