U.S. Route 66 is a highway in the United States, running from Illinois to California.
History[]
Scooby-Doo and Guess Who?[]
Mystery Inc. drove along Route 66 for tourism, but were attacked by three Mud Men who stole the Mystery Machine. They were forced to travel to the nearby town of Miloville on foot, where they met musician Axl Rose at the Sunny Side Up Diner. They worked together to investigate the Mud Men, and after discovering their motives, they chased the Mud Men on Route 66 and forced them to crash, capturing them.