Mrs. Blake refers to the mother of Daphne Blake.
- Elizabeth Blake: The mother of standard continuity Daphne, who appeared in The New Scooby and Scrappy Doo Show and A Pup Named Scooby-Doo.
- Mrs. Blake: Daphne mentioned both of her parents in the Scooby-Doo! The Mystery Begins continuity.
- Nan Blake: The mother of Daphne from the Scooby-Doo! Mystery Incorporated continuity.
- Mrs. Blake: The mother of Daphne from the Be Cool, Scooby-Doo! continuity.
- Mrs. Blake: The mother of Daphne in the Scooby Apocalypse continuity.
- Elizabeth Blake: The mother of Daphne in the Daphne & Velma continuity.