Mr. Hyde may refer to the following:
- Ghost of Mr. Hyde: The disguise of Dr. Jekyll, from the Scooby-Doo, Where Are You! episode Nowhere to Hyde.
- Mr. Hyde: The disguise of Zalia Z. Fairchild, from the The New Scooby-Doo Movies episode Sandy Duncan's Jekyll and Hyde.
- Mr. Hyde: The transformation of Willie the Weasel, from the Dynomutt, Dog Wonder episode Everyone Hyde!
- Dr. Jackyll: A parody of Mr. Hyde from the TV film Scooby-Doo and the Reluctant Werewolf.
- Mr. Hyde: From the DC Comics' Scooby-Doo story The Library Lurker.
- Mr. Hyde: The disguise of Izzy Fenwick, from the Scholastic's Scooby-Doo! and You: The Case of Dr. Jenkins and Mr. Hyde in the Scooby-Doo! and You book series.
- Mr. Hyde: The disguise of Jack Rabble, from the DTV Scooby-Doo! Mask of the Blue Falcon.
- Hyde Monster: The disguise of Tabitha from the Scooby-Doo and Guess Who? episode The Dreaded Remake of Jekyll & Hyde!.